They demonstrated an overexpression of GPC-3 in tissues from salivary gland tumors, including in 11 out of 17 pleomorphic adenomas, compared to healthy tissue; however, this expression was more frequent and more substantial in malignant tumors than in benign ones (64.7% for PA vs. 82.4% for ACC vs. 87.5% for MEC) [51]. This evidence concerns the gene GPC3 and adrenal cortex carcinoma.