Recently, He et al. demonstrated that exosomal circEHD2, regulated by heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2B1), was transferred to fibroblasts and converted fibroblasts to CAFs in renal cell carcinoma (RCC) [183]. The gene discussed is HNRNPA2B1; the disease is hereditary clear cell renal cell carcinoma.