NFKB1 and hepatocellular carcinoma: In addition to the proangiogenic phenotype, Fang et al. demonstrated that high-metastatic HCC cells secrete exosomal miR-1247-3p, which directly targets B4GALT3, leading to the activation of β1-integrin-NF-κB signaling in CAFs, and then activated CAFs boosted the development of tumor by secreting multiple proinflammatory cytokines, such as IL-6 and IL-8 [170].