CD8A and neoplasm: Significant accumulations of senescent CD8+ T cells have been identified in the tumor-infiltrating lymphocytes (TILs) associated with diverse types of cancers, which sustain and magnify the suppressive tumor microenvironment by potently inhibiting the proliferation of reactive T cells, including those in AML, multiple myeloma (MM), melanoma, and breast cancer [7,8,9,10].