TMEM127 and hereditary pheochromocytoma-paraganglioma: In the TMEM127 gene, a missense alteration (NM_017849.4):c.419G>A, p.(Cys140Tyr) was found in a female patient with a personal history of breast cancer diagnosed at 45 years of age presenting with one family member with breast cancer but no individual or family history for pheochromocytoma or paraganglioma.