These variants span over 17 genes (ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, CDKN2A, MLH1, MSH2, NF1, PALB2, PMS2, PTEN, RAD51C, RAD51D, and TP53) associated with elevated risk for HBOC tumours according to NCCN guidelines (Figure 1, Table 2, Supplementary Figure S1). This evidence concerns the gene MLH1 and neoplasm.