Indeed, when Exo@TDPs were intravenously injected into the BALB/c mice bearing wild-type U251 GBM tumors in the brain, they were found in the deep tumor parenchyma 24 h after injection, and their homing efficiency was higher with respect to EXO not decorated by Ang2/CD133-targeted peptides. The gene discussed is PROM1; the disease is glioblastoma.