miR-1 is also a tumor suppressor in different types of cancer [89]: Bronisz et al. found that miR-1 could be transferred by GDEs to the surrounding GBM cells, reducing GBM growth and invasion through directly targeting the expression of an important pro-oncogenic factor in GBM, Annexin A2 (ANXA2) [90]. Here, ANXA2 is linked to neoplasm.