In our study, 10q11.23 (PRKG1), 10q22.1 (CSTF2T), 10p12.33 (MRC1), and 10p12.1 (STAM) occurred in 37.5% of ChRCC and not in RO, indicating the potential of the two cytobands in differentiating the two tumours. The gene discussed is PRKG1; the disease is chromophobe renal cell carcinoma.