Scopolamine is a non-selective muscarinic cholinergic receptor (mACh Rs) antagonist, known to induce deficiencies in memory and cognition elicited by dysfunction of the brain’s cholinergic system, enhanced oxidative stress and impaired antioxidants defense, neuroinflammation, unfavorable changes in the monoaminergic neurotransmitter systems, mitochondrial alterations, apoptosis, and compromised BDNF signaling [34], pathological changes accompanying AD as well [35,36,37,38,39,40,41,42,43]. Here, CASP8 is linked to Alzheimer disease.