Piperine, as a potent inhibitor of dihydroorotic acid dehydrogenase (DHODH), demonstrated strong prophylactic and therapeutic effects in MOG (myelin oligodendrocyte glycoprotein)-induced experimental autoimmune encephalomyelitis (EAE) by restricting the infiltration of inflammatory cells into the CNS and preventing myelin and blood–brain barrier (BBB) disruption, proving a novel role for piperine in the treatment of MS [94]. This evidence concerns the gene MOG and experimental autoimmune encephalomyelitis.