In addition, the activation of microglia, which exhibit M1 and M2 phenotypes, plays an important role in AD’s pathology; CAP regulates microglial activation by inhibiting AKT/mTOR pathway activity and reduces neuronal degeneration, reversing spatial memory deficits [21,42,43,44,46,47] (Figure 2). This evidence concerns the gene AKT1 and Alzheimer disease.