CHRNA7 and Parkinson disease: In another study, the CUR agonism of human α7-nicotine-acetylcholine receptor (α7-nAChR) decreased the mortality of DA neurons in the substantia nigra and significantly reduced 6-OHDA-induced dyskinesia in mice with PD, suggesting that the activation of α7-nAChR by CUR has neuroprotective effects in PD [127].