Hydroxyisoxazole-4-carboxylic acid (HICA) [138] and 1-(phenylseleno)-4-(trifluoromethyl) benzene (PSTMB) [139] also act as pyruvate competitors, inhibiting LDHA and disrupting mitochondrial membrane integrity, thereby inhibiting the proliferation of human colon cancer cells. The gene discussed is LDHA; the disease is malignant colon neoplasm.