Since the pre-erythrocytic stage of Plasmodium infection affects the liver and this same organ is the site for biotransformation of drugs and drug candidates, we further evaluated the effects of this infection and drug on the liver cells via the activities of aspartate, alanine aminotransferases (AST, ALT), lactate dehydrogenase (LDH), and alkaline phosphatase (ALP). This evidence concerns the gene GPT and infection.