The M2BPgs-HCC score showed much better performance than that of AFP-L3% [p = 6.26 × 10−5, AUC = 0.726, sensitivity = 45.2%, specificity = 100%] or log10[PIVKA-II] [p = 1.54 × 10−5, AUC = 0.741, sensitivity = 52.4%, specificity = 100%]. The gene discussed is AFP; the disease is hepatocellular carcinoma.