Here, we discuss the impact of irisin on the NLRP3 inflammasome pathway, as well as the potential role of this pathway in Parkinson’s disease (PD), AD, and amyotrophic lateral sclerosis (ALS), and the therapies that target the NLRP3 inflammasome [34,35,36]. This evidence concerns the gene FNDC5 and amyotrophic lateral sclerosis.