ALB and neoplasm: This probe rapidly decomposed in the tumor cells in the presence of lysosomal acid pH and GSH, producing high r1 Mn2+ ions, which were sequentially captured/retained and re-amplified by extravascular albumin in the tumor in vivo, as detected by T1w MRI of HT-29 tumor Balb/c mice, as well as SPECT-CT using 99mTc-labeled probes and OI and PAI of CyT5-labeled probes [105].