Reactome processes implicated in RA pathogenesis such as the RUNX1 pathway, the formation of the beta-catenin:TCF transactivating complex, RHO GTPases activating PKNs, and signaling by WNT were also enriched among the DEGs in synovial tissues (Figure 2A, Supplemental Table S1). The gene discussed is RUNX1; the disease is rheumatoid arthritis.