GPT and obesity due to melanocortin 4 receptor deficiency: Moreover, participants who gained weight, moving from a normal weight to overweight/obesity, had a 114% higher risk of SLD (HR 2.14, 95% CI, 1.81–2.53) and a 62% higher risk of ALT elevation (HR 1.62, 95% CI, 1.30–2.01) compared with those who maintained a normal weight (Table 2).