The results showed that individuals who lost weight and transitioned from overweight/obesity to a normal weight had a 71% lower risk of SLD (HR, 0.29, 95% CI, 0.20–0.44), a 60% lower risk of ALT elevation (HR, 0.40, 95% CI, 0.25–0.66), and a 67% lower risk of AST elevation (HR, 0.33, 95% CI, 0.18–0.60) compared with stable overweight/obese individuals. The gene discussed is GPT; the disease is Obesity.