For instance, luteolin alleviates diabetic dyslipidemia in rats by modulating Acyl-coenzyme A:cholesterol acyltransferase-2 (ACAT-2), peroxisome proliferator-activated receptor alpha (PPARα), sterol regulatory element binding protein-2 (SREBP-2) protein, and oxidative stress in rats with T2DM induced by HFD/STZ. This evidence concerns the gene SOAT2 and type 2 diabetes mellitus.