Deshmukh et al. reported that dietary supplementation of PSE restored the T2DM-induced changes in (i) mitochondrial function-associated parameters, such as fission (DRP1), fusion (MFN1, MFN2, OPA1), biogenesis (TFAM, PGC-1α), and mitophagy (PINK1), and (ii) inflammation (TNF-α) in the liver of db/db mice [25]. The gene discussed is PPARGC1A; the disease is type 2 diabetes mellitus.