Such suppression of Nfkb1 gene expression in the liver of PSE-supplemented diabetic mice is consistent with Fatimawali’s study using anti-inflammatory bioactive compounds, namely Clerodendrum minahassae leaf extract, for managing T2DM via interacting with and inhibition of Nfkb in the insulin signal transduction pathway [59]. The gene discussed is INS; the disease is type 2 diabetes mellitus.