Our analysis of 29 studies reveals that curcumin, silymarin, and hesperidin demonstrate significant potential in ameliorating critical markers of liver dysfunction, including a reduction in liver enzymes (AST, ALT, and GGT), improvement in lipid profile (LDL, HDL, TC, and TG), and reduction in inflammatory cytokines (TNF-α, IL-6, and CRP). The gene discussed is IL6; the disease is Decreased liver function.