The authors found that a total of 24 variants across five genes that had not been previously linked to AMD (BCMO1, BCO2, NPCL1L1, ABCG8, and FADS2), along with four genes known to be associated with AMD (SCARB1, ABCA1, APOE, and ALDH3A2), were independently associated with AMD after adjusting for age and ancestry [96]. Here, APOE is linked to age-related macular degeneration.