Significant associations with 25(OH)D were also found for SNPs in genes GC, VDR, CYP2R1, and CYP27B1: 2 SNPs (VDR) were associated with early AMD, 4 SNPs (RXRA), and 1 SNP (VDR) were associated with neovascular AMD, and 1 SNP (RXRA), 2 SNPs (VDR), and 1 SNP (CYP2R1) were associated with late AMD. This evidence concerns the gene CYP27B1 and age-related macular degeneration.