APOE and age-related macular degeneration: One study noted significant increases in serum amyloid A in AMD patients, while other HDL components, such as apolipoproteins A-I (APOA1), A-II (APOA2), C-III, E (APOE), TG, phospholipids, fatty acids of HDL, and total and non-esterified cholesterol, showed no difference compared to controls [116].