TNFRSF10B and breast carcinoma: Follow-up studies also reported that γT induced apoptosis in human breast cancer cells by increasing cellular ceramides (Cer) and dhCer levels and activating the c-Jun N-terminal kinase (JNK)/CCAAT/enhancer-binding protein homologous protein (CHOP)/death receptor-5 (DR5) proapoptotic signaling pathway [41,43].