In a living organism investigative framework for acute promyelocytic leukemia (APL), notably the PML/RARα fusion (retinoic acid receptor α) model, the consumption of green tea demonstrated the ability to increase reactive oxygen species (ROS) levels in Gr1+ cells in bone marrow and decrease the number of CD34+ and CD117+ cells at the same time. Here, RARA is linked to acute promyelocytic leukemia.