Although the plasma glucose levels immediately prior to starting exercise were similar between the groups following the two feeding strategies, the synergistic and, indeed, additive glucose-lowering effects of peripheral hyperinsulinemia and working skeletal muscle tissue actions in the PEC group likely promoted an increased rate of intramuscular glucose uptake over the 45-min cycling session (regression analyses, with circulating insulin at exercise onset and the Δ in glucose over exercise β = −0.603, p = 0.013). Here, INS is linked to Hyperinsulinemia.