IDH3A and Alzheimer disease: For instance, Sang et al. examined six postmortem brain regions affected by Alzheimer’s disease and identified significant perturbations in mitochondrial TCA cycle enzymes, such as pyruvate dehydrogenase complex, isocitrate dehydrogenase, 2-oxoglutarate dehydrogenase complex, and succinyl-CoA synthetase, all of which are directly or indirectly regulated by CoA [54].