The different roles of SIRT2 in apoptosis, via p53 regulation, as well in cell cycle progression have been reported across several studies which has led to further interest in terms of studying the action of this protein in the context of cancer progression [55,56,57,58]; however, its function as a tumor regulator varies according to the cellular context or the type of tumors present in the cell [57]. The gene discussed is TP53; the disease is neoplasm.