VDA alone and in association with retinoic acid (9-cis RA)significantly inhibited cell growth. VDA diminished apoptosis induced by 9-cis RA in tumor cells via caspase inactivation. EB1089 upregulates p21, but not p27. Akt phosphorylation is not reduced by EB1089. The gene discussed is CDKN1A; the disease is neoplasm.