CDKN1A and hypercalcemia disease: In vitro, VDAs inhibited proliferation and caused G1Phase cell cycle arrest. In vivo, maxacalcitolInhibited the growth of BxPC-3 xenografts more significantly than calcitriol, without inducing hypercalcemia. Inresponsive cells, p21 and p27Were markedly upregulated after treatment withBoth agents. In non-responsive cells, no such changes were observed.