Reduced levels of BECN1, as well as other proteins, i.e., autophagy-activating kinase Unc-511 (ULK1), p-ULKs555, ATG5, p62/SQSTM1 and BCL2 interacting protein 3 (BNIP3), have been reported in liver samples from MASLD patients compared to control patients with healthy livers, suggesting the impaired initiation of autophagy and autophagosome formation. Here, BNIP3 is linked to metabolic dysfunction-associated steatotic liver disease.