CGREF1 and fatty liver disease: Although CGREF1 is not a factor considered crucial for processes involving lipid and cholesterol metabolism, its identification as one of two genes with altered expression common to the Geneva and Hayward kiwifruit varieties suggests that the activity of this gene may be key to reducing hepatic steatosis in response to the use of freeze-dried kiwifruit containing antioxidants, fiber, and vitamins as supplements in a high-cholesterol diet.