IGHE and allergic disease: According to the EAACI, patients with an IgE-mediated allergy and a history of previous anaphylactic reactions triggered by food, with unstable or moderate to severe persistent asthma and systemic mastocytosis, should have easy access to adrenaline auto-injectors and be educated on recognizing and self-managing recurrence of the anaphylactic reactions [27,68,69].