AGT and hypertensive disorder: Hypertension is typically characterized by the overactivation of the sympathetic nervous system (SNS) and the renin–angiotensin–aldosterone system (RAAS), leading to the excessive production of catecholamines, angiotensin II, and aldosterone, with consequent vasoconstriction, increased heart rate, cardiac hypertrophy, and sodium and water reabsorption [31].