Polysaccharides from the aboveground part of Angelica sinensis (ASP-Ag-AP) exhibited protective effects against dextran sodium sulfate (DSS)-induced colitis by inhibiting the TLR4/MyD88/NF-κB signaling pathway and restoring serum levels of the metabolite 5-methyl-dl-tryptophan (5-MT), thus reducing colonic inflammation and enhancing barrier function while modulating the gut microbiota [60]. This evidence concerns the gene NFKB1 and colitis.