It is crucial to note that protein C and protein S, both vitamin K-dependent proteins found in the plasma compartment, function together as an anticoagulant system to inhibit excessive blood coagulation, with protein S acting as the primary cofactor for protein C. Nevertheless, reduced levels of these anticoagulant proteins, such as protein C and protein S, have been observed in patients with thalassemia, potentially leading to a hypercoagulable condition [35,36]. The gene discussed is PROS1; the disease is thalassemia.