Supportive treatment utilizing EGCG-rich green tea extract (GTE) tablets in patients with thalassemia major (TDT) experiencing iron overload may enhance the activities and concentrations of key anticoagulant proteins, specifically protein C and protein S. Furthermore, these GTE tablets demonstrated significant inhibitory effects on platelet aggregation induced by ADP and collagen, in addition to their antioxidant, reactive oxygen species (ROS) scavenging, and iron-chelating capabilities. This evidence concerns the gene PROS1 and beta thalassemia.