Many confounding factors can be attributed to abnormal hemostasis in patients with thalassemia, including microparticles (MPs) obtained from PLT, leucocytes and vascular endothelial cells, RBC vesicles, plasminogen activator inhibitor 1, RBC phosphatidylserine exposure, plasma NO•, β2-thromboglobulin (β2-TG), and splenectomy status [23,24]. The gene discussed is SERPINE1; the disease is thalassemia.