AKT1 and osteoporosis: Characteristic phenolic compounds in genus Curculigo, such as curculigoside and orcinol glucoside, have also been shown to treat osteoporosis in vivo and in vitro through signaling pathways such as Wnt/β-catenin, Akt/FoxO1, Nrf2/Keap1, and mTOR [18,19,20,21].