In oral squamous cell carcinoma, LDOC1 inhibited microbe-induced IL-1β production by regulating the phosphoinositide 3-kinases (PI3K)/protein kinase B (Akt)/phospho-glycogen synthase kinase 3 beta (pGSK-3β) signaling pathway [50]. Here, AKT1 is linked to oral cavity squamous cell carcinoma.