LEPR and type 2 diabetes mellitus: Other genetically based models reproduce obese forms of T2D, like those due to leptin deficiency (BTBR ob/ob mice, [71]) or leptin receptor deficiency (db/db mice, [72]; ZDK rats, [73]), or non-obese T2D models, like the polygenic model provided by the Goto-Kakizaki rats [74].