NEXN and familial dilated cardiomyopathy: Along with these observations, a conventional nexilin-deficient mouse model generated by crossing floxed Nexnfl/fl mice with Sox2-Cre deleter mice also showed no histological abnormalities up to embryonic day 18.5 but rapidly developed severe cardiac enlargement, decreased fractional shortening percentage, and DCM which resulted in early death at day P12 [5].