To note, however, only control mice showed a reduction in MyRF+GFP+ cell density upon cuprizone treatment (0.73 ± 0.04, p = 0.021), whereas OPC-GABABR cKD mice did not show any difference compared to untreated animals (1.05 ± 0.12, p = 0.723) (Figure 3F). Here, MYRF is linked to chronic kidney disease.