Specifically, in the white matter, the relative number of PDGFRα+GFP+ was increased in cKD mice (ctrl, 75.62 ± 4.95%; cKD, 88.20 ± 2.08%; p = 0.011), suggesting a reduced OPC differentiation in cKD mice (Figure 1H). This evidence concerns the gene PDGFRA and chronic kidney disease.