Although the mean MBP fluorescence intensity was only slightly enhanced in cKD compared to control mice (ctrl, 7.80 ± 0.65; cKD, 9.10 ± 0.94; p = 0.371) (Figure 4C), MBP was reduced compared to untreated conditions specifically in control mice (0.72 ± 0.06, p = 0.018), but unaltered in cKD mice (0.96 ± 0.10, p = 0.703) (Figure 4D). Here, MBP is linked to chronic kidney disease.