PDGFRA and chronic kidney disease: On the other hand, the MyRF+GFP+/PDGFRα+GFP+ ratio was almost doubled in cKD mice compared to untreated mice (1.86 ± 0.07, p = 0.001), whereas it was reduced in control mice (0.69 ± 0.08, p = 0.029) (Figure 3K), in line with the enhanced OPC differentiation after the loss of the OPC-GABABR.