In line with this, we detected a strong glial response upon LPC incubation on the superficial layers of the dorsal white matter tracts in control and cKD mice (Supplementary Figure S6A,B), both in terms of astroglial GFAP expression (Supplementary Figure S6C,D) and Iba1+ microglia activation (Supplementary Figure S6E,F). The gene discussed is AIF1; the disease is chronic kidney disease.