However, in our study the reverse situation is operating; NED occurs in poorly differentiated mesenchymal cancer cells, which matches our findings on the co-localization of CHGA, SSTR2, and SYP with CK7 and VIM in the neoplastic ductal cells in tissue sections of PDAC specimens, in particular a large (T3) and poorly differentiated (G3) tumor (Figure 3). This evidence concerns the gene SYP and cancer.