IL1RAP and idiopathic pulmonary fibrosis: However, fewer interleukin (IL6, IL1RAP), MMPs (MMP1), and growth factor-related (FLT4/VEGFR3) genes were observed in the diseased state (Table S5) as compared to non-diseased lung fibroblasts (Table S3), which could potentially be due to increased WISP1 leading to desensitization of the Wnt-1 associated downstream signaling pathway in an IPF-diseased state.