AGT and Hypertension: In addition, the activation of many intracellular non-receptor tyrosine kinases by Ang II, such as Src family kinases, Ca2+-dependent tyrosine kinases (e.g., Pyk2), p130Cas, FAK, phosphatidylinositol 3-kinase (PI3K), and JAK2/TYK2 (Janus kinase), is also associated with altered VSMC function in hypertension [66].