AGTR1 and Hypertension: As discussed above, the stimulation of the AT1R by Ang II increases the release of cytokines, IL-6, and NOXs from endothelial cells, results in the production of vasoconstrictor agents from VSMCs, and further leads to vascular remodeling (e.g., aortic wall thickening) and hypertension (e.g., pressure overload).