Although abundant progress in animal studies has been made to illustrate the pivotal role of macrophages in Ang II-mediated cardiovascular dysfunction, translating these findings from the experimental findings into clinical practice needs additional investigation, particularly focusing on mechanisms of protective action underlying the inhibition of Ang II/AT1R/macrophage axis-induced cardiac pathologies, such as hypertension, maladaptive cardiac repair, fibrosis, and heart failure progression. The gene discussed is AGT; the disease is heart failure.