In the mouse model of TAC, the pressure overload results in the early upregulation of CCL2, CCL7, CCL12 chemokines, and CCR2+ infiltrating macrophages in the heart, along with an increase in the concentration of Ly6ChighCCR2+ monocytes in the blood at 1 week post-TAC. This evidence concerns the gene CCL7 and persistent truncus arteriosus.