Here, we describe the phenotypes of tissue-resident macrophages and monocyte-derived macrophages in the cardiovascular system, define their physiological role in tissue homeostasis, and discuss their pathological role in the development of hypertension, hypertrophy, tissue fibrosis, and heart failure, primarily in the context of Ang II-mediated remodeling signaling pathways. Here, AGT is linked to Hypertension.