Regulated by BRN2/BRN4, causes cell lineage reprogramming to a neuroendocrine phenotype. Suppressed by RB1 and TP53 in adenocarcinoma cells. Promotes lineage plasticity and enzalutamide resistance with loss of TP53 and RB1. Regulates ASCL1. The gene discussed is TP53; the disease is adenocarcinoma.