SRRM4 and adenocarcinoma: In the study, SRRM4 expression levels were found to be comparatively upregulated in NEPC with respect to adenocarcinoma samples in both datasets, and the researchers demonstrated a negative association with the expression of SRRM4 and the master transcriptional regulator RE1-silencing TF (REST), which silences neuronal genes in non-neuronal cells, preventing differentiation.