MTOR and hepatocellular carcinoma: Several signaling pathways have been implicated in the development of HCC, including the Ras/Raf/MAPK, PI3K/Akt/mTOR, JAK/STAT, Wnt/β-catenin, Hippo, Notch, and Hedgehog pathways, which contribute to HCC by influencing the biological behaviors of hepatocytes, such as proliferation, differentiation, apoptosis, metastasis, and angiogenesis [5].