We then obtained data from patients with HNSCC and OSCC from the TCGA database and GSE40774, categorized the patients on the basis of HPV status, and compared Mena expression levels in the patients, which indicated that Mena expression levels were significantly greater in HPV-negative cancers than in HPV-positive cancers (both HNSCC and OSCC, p < 0.001), which is consistent with the results above (Figure 1B). Here, ENAH is linked to head and neck squamous cell carcinoma.