A systematic study unified spatial gene expression, structural MRI, and cell deconvolution to characterize large-scale spatial associations between canonical cell types and brain tissue loss across cortical and subcortical grey matter areas in 13 neurodegenerative diseases—early-onset and late-onset AD, PD, DLB, amyotrophic lateral sclerosis, mutations in presenilin 1, clinical (behavioral FTD, nonfluent variant primary progressive aphasia [PPA], semantic variant PPA) and pathological subtypes of frontotemporal lobar degeneration [67]. The gene discussed is PSEN1; the disease is Lewy body dementia.