Among the polymorphisms playing roles in PCa etiology, those in genes encoding AR, the prostate-specific antigen (PSA), SRD5A2, CYP17A1, CYP3A4, and a putative hereditary PC susceptibility 2 protein (HPC2/ELAC2) have been suggested [241]. This evidence concerns the gene CYP17A1 and posterior cortical atrophy.