The combination of the CYP3A5*3/*3 and SRD5A2 A49T GG genotypes was associated with tumor clinical stages T2–T4, whereas the CYP3A5*3/*3 and KLK3 I179T CC/TC genotypes had increased OS in patients with metastatic PCa [261]. This evidence concerns the gene CYP3A5 and neoplasm.