HMGB1 and crescentic glomerulonephritis: Studies with crescentic glomerulonephritis mice model suggest that the rise in renal HMGB1 level occurs primarily via the nucleotide-binding oligomerization domain leucine rich repeat and pyrin domain containing 3 (NLRP3)/apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) inflammasome activation and local HMGB1 release in glomeruli [88,89].