For instance, in Alzheimer’s disease, metabolic inflammation is associated with insulin resistance in the brain, which leads to impaired glucose metabolism and the subsequent accumulation of toxic amyloid-beta plaques and hyperphosphorylated tau proteins, which contributes to the neuronal dysfunction and cell death that characterizes this disease, bringing attention to the link between metabolic health and brain function. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.