However, these cells have functional plasticity and can evolve into tissue repair anti-inflammatory M2 macrophages [22,23], induced by M2 polarizing cytokines (CCL2, IL-10, and TGF-β) and bone morphogenetic protein 4 (BMP-4) produced by bladder tumors [24,25]. This evidence concerns the gene BMP4 and urinary bladder neoplasm.