ITGB2 and acute promyelocytic leukemia: Considering the challenges associated with the genetic modification of human eosinophils and the inability to conduct functional screenings with mouse eosinophils due to the specificity of the lncRNA ITGB2-AS1 to human cells, we employed the human promyelocytic leukemia cell line HL-60 clone 15 (HL-60c15, ATCC CRL-1964) for genetic modifications and subsequent functional studies [35,46].