RETN and cardiac hypertrophy: Resistin also modulates the renin–angiotensin–aldosterone system, promoting hypertensive responses and aggravating HF progression Animal models have provided strong evidence of resistin’s impact: studies involving adenoviral overexpression of resistin demonstrated significant myocardial hypertrophy, impaired LV contractility, and fibrosis in rats, mirroring the pathological features observed in HFpEF patients [91,92,93,94,95].