Compared to the lowest quartile (Q1), the highest adiponectin quartile (Q4) was associated with significantly elevated hazards for all-cause mortality (HR 2.27; 95% CI 1.47–3.50; p = 0.0002), CVD mortality (HR 2.43; 95% CI 1.15–5.15; p = 0.02), major adverse cardiovascular and cerebrovascular events (MACCE) (HR 1.71; 95% CI 1.13–2.60; p = 0.01), and HF (HR 2.95; 95% CI 1.14–7.67; p = 0.03), after adjusting for potential confounders, such as age, sex, race, BMI, hypertension, diabetes, and inflammatory markers. This evidence concerns the gene ADIPOQ and Hypertension.