Multivariate analysis (ANOVA) performed for the control, gestational hypertension without pre-eclampsia, and gestational hypertension with pre-eclampsia groups showed a significant interaction between groups for MR-proANP [H(2, 59) = 17.267; p < 0.001] and adrenomedullin [H(2, 59) = 25.910; p < 0.001] concentrations. This evidence concerns the gene ADM and preeclampsia.