At the same time, serum levels of calcitonin and osteoprotegerin were significantly lower in frail CAD patients (2.60 [1.50; 5.85] pg/mL, p = 0.018; 0.80 [0.60; 1.20] ng/mL, p = 0.025, respectively) in terms of the entire spectrum of studied biological markers of inflammation and musculoskeletal and fat remodeling. The gene discussed is TNFRSF11B; the disease is coronary artery disorder.